Gene information
Official symbol INS
Official full name insulin
Gene type protein-coding gene
Chromosome11p15.5
Previous symbolIDDM2; IDDM1
Gene familyNeuropeptides
Resources
Entrez Gene 3630
HGNC HGNC:6081
Ensembl ENSG00000254647
Vega OTTHUMG00000009558
UCSC uc001lvo.2
GO terms: 205 records
GO Description Category LogP Number of genes Detail
GO:0000139 Golgi membrane GO Cellular Components -1.63315191 17 More
GO:0001558 regulation of cell growth GO Biological Processes -19.1123936 65 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0002020 protease binding GO Molecular Functions -28.8254555 31 More
GO:0002526 acute inflammatory response GO Biological Processes -34.5980034 29 More
GO:0002674 negative regulation of acute inflammatory response GO Biological Processes -4.88157794 4 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002698 negative regulation of immune effector process GO Biological Processes -11.7829906 16 More
GO:0002793 positive regulation of peptide secretion GO Biological Processes -7.26567394 18 More
GO:0002831 regulation of response to biotic stimulus GO Biological Processes -10.931136 25 More
GO:0002832 negative regulation of response to biotic stimulus GO Biological Processes -3.02904053 13 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0005158 insulin receptor binding GO Molecular Functions -2.72529058 5 More
GO:0005159 insulin-like growth factor receptor binding GO Molecular Functions -3.41433421 5 More
GO:0005179 hormone activity GO Molecular Functions -33.3562443 33 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO Cellular Components -2.09961494 6 More
GO:0005796 Golgi lumen GO Cellular Components -14.6918478 18 More
GO:0005975 carbohydrate metabolic process GO Biological Processes -4.30473825 38 More
GO:0005979 regulation of glycogen biosynthetic process GO Biological Processes -6.48443546 10 More
GO:0006109 regulation of carbohydrate metabolic process GO Biological Processes -13.1742479 35 More
GO:0006110 regulation of glycolytic process GO Biological Processes -6.41532756 12 More
GO:0006111 regulation of gluconeogenesis GO Biological Processes -5.35833465 7 More
GO:0006140 regulation of nucleotide metabolic process GO Biological Processes -7.41911571 18 More
GO:0006953 acute-phase response GO Biological Processes -24.9631834 19 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007088 regulation of mitotic nuclear division GO Biological Processes -2.33218274 6 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008286 insulin receptor signaling pathway GO Biological Processes -3.0699689 9 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009895 negative regulation of catabolic process GO Biological Processes -10.3621088 43 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0010565 regulation of cellular ketone metabolic process GO Biological Processes -15.3155739 32 More
GO:0010638 positive regulation of organelle organization GO Biological Processes -6.49207636 47 More
GO:0010675 regulation of cellular carbohydrate metabolic process GO Biological Processes -9.60411715 27 More
GO:0010676 positive regulation of cellular carbohydrate metabolic process GO Biological Processes -6.37680507 13 More
GO:0010827 regulation of glucose transmembrane transport GO Biological Processes -18.4601079 28 More
GO:0010828 positive regulation of glucose transmembrane transport GO Biological Processes -9.82015489 15 More
GO:0010906 regulation of glucose metabolic process GO Biological Processes -10.3110629 25 More
GO:0010907 positive regulation of glucose metabolic process GO Biological Processes -8.00848642 13 More
GO:0010962 regulation of glucan biosynthetic process GO Biological Processes -6.48443546 10 More
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -15.9250248 30 More
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -18.2876323 28 More
GO:0019932 second-messenger-mediated signaling GO Biological Processes -19.1717114 46 More
GO:0019934 cGMP-mediated signaling GO Biological Processes -6.05074470 6 More
GO:0019935 cyclic-nucleotide-mediated signaling GO Biological Processes -6.37341307 8 More
GO:0022898 regulation of transmembrane transporter activity GO Biological Processes -11.1988499 41 More
GO:0030133 transport vesicle GO Cellular Components -1.60876030 12 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030307 positive regulation of cell growth GO Biological Processes -13.7154299 34 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031330 negative regulation of cellular catabolic process GO Biological Processes -6.88355184 32 More
GO:0031344 regulation of cell projection organization GO Biological Processes -8.91314416 62 More
GO:0031346 positive regulation of cell projection organization GO Biological Processes -6.78114948 37 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0031904 endosome lumen GO Cellular Components -9.27147512 9 More
GO:0031952 regulation of protein autophosphorylation GO Biological Processes -4.76981182 6 More
GO:0031954 positive regulation of protein autophosphorylation GO Biological Processes -3.46447442 4 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032147 activation of protein kinase activity GO Biological Processes -11.6086663 28 More
GO:0032148 activation of protein kinase B activity GO Biological Processes -8.71311579 12 More
GO:0032409 regulation of transporter activity GO Biological Processes -16.9480646 53 More
GO:0032768 regulation of monooxygenase activity GO Biological Processes -14.2762890 21 More
GO:0032770 positive regulation of monooxygenase activity GO Biological Processes -9.70418585 13 More
GO:0032868 response to insulin GO Biological Processes -11.6850377 35 More
GO:0032869 cellular response to insulin stimulus GO Biological Processes -9.16399556 26 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0032881 regulation of polysaccharide metabolic process GO Biological Processes -7.60302561 13 More
GO:0032885 regulation of polysaccharide biosynthetic process GO Biological Processes -7.40593429 12 More
GO:0033238 regulation of cellular amine metabolic process GO Biological Processes -3.34516618 7 More
GO:0033500 carbohydrate homeostasis GO Biological Processes -23.7918768 50 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042110 T cell activation GO Biological Processes -7.78997285 18 More
GO:0042176 regulation of protein catabolic process GO Biological Processes -8.45353494 23 More
GO:0042177 negative regulation of protein catabolic process GO Biological Processes -5.18322511 10 More
GO:0042593 glucose homeostasis GO Biological Processes -23.8963802 50 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043255 regulation of carbohydrate biosynthetic process GO Biological Processes -8.87798147 21 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0043467 regulation of generation of precursor metabolites and energy GO Biological Processes -10.8295915 27 More
GO:0043470 regulation of carbohydrate catabolic process GO Biological Processes -8.06132628 15 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0045088 regulation of innate immune response GO Biological Processes -6.98001665 16 More
GO:0045321 leukocyte activation GO Biological Processes -25.4958219 48 More
GO:0045725 positive regulation of glycogen biosynthetic process GO Biological Processes -5.96315455 7 More
GO:0045821 positive regulation of glycolytic process GO Biological Processes -6.91942497 9 More
GO:0045824 negative regulation of innate immune response GO Biological Processes -2.94039732 10 More
GO:0045833 negative regulation of lipid metabolic process GO Biological Processes -7.94928400 20 More
GO:0045840 positive regulation of mitotic nuclear division GO Biological Processes -3.57424917 5 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0045913 positive regulation of carbohydrate metabolic process GO Biological Processes -10.1978214 20 More
GO:0045922 negative regulation of fatty acid metabolic process GO Biological Processes -4.09043632 8 More
GO:0045927 positive regulation of growth GO Biological Processes -20.3035639 52 More
GO:0045981 positive regulation of nucleotide metabolic process GO Biological Processes -9.35726225 15 More
GO:0046324 regulation of glucose import GO Biological Processes -14.8736114 22 More
GO:0046326 positive regulation of glucose import GO Biological Processes -7.69659659 12 More
GO:0046626 regulation of insulin receptor signaling pathway GO Biological Processes -7.79385832 16 More
GO:0046631 alpha-beta T cell activation GO Biological Processes -4.13140497 7 More
GO:0046649 lymphocyte activation GO Biological Processes -10.1732143 26 More
GO:0046887 positive regulation of hormone secretion GO Biological Processes -9.61661717 24 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048167 regulation of synaptic plasticity GO Biological Processes -4.27696718 22 More
GO:0050708 regulation of protein secretion GO Biological Processes -30.3716714 63 More
GO:0050709 negative regulation of protein secretion GO Biological Processes -12.5236372 21 More
GO:0050714 positive regulation of protein secretion GO Biological Processes -15.7339081 32 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050777 negative regulation of immune response GO Biological Processes -11.1440698 32 More
GO:0050795 regulation of behavior GO Biological Processes -5.81792293 14 More
GO:0050803 regulation of synapse structure or activity GO Biological Processes -6.38009123 27 More
GO:0050804 modulation of chemical synaptic transmission GO Biological Processes -15.2260557 60 More
GO:0050806 positive regulation of synaptic transmission GO Biological Processes -4.32260958 18 More
GO:0050807 regulation of synapse organization GO Biological Processes -6.08931613 26 More
GO:0050890 cognition GO Biological Processes -8.00500082 37 More
GO:0050999 regulation of nitric-oxide synthase activity GO Biological Processes -9.05830591 14 More
GO:0051000 positive regulation of nitric-oxide synthase activity GO Biological Processes -5.74582458 8 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051047 positive regulation of secretion GO Biological Processes -32.2282376 71 More
GO:0051048 negative regulation of secretion GO Biological Processes -20.2278199 42 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0051091 positive regulation of DNA-binding transcription factor activity GO Biological Processes -17.7436786 49 More
GO:0051092 positive regulation of NF-kappaB transcription factor activity GO Biological Processes -14.8614421 21 More
GO:0051222 positive regulation of protein transport GO Biological Processes -13.8994291 46 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0051224 negative regulation of protein transport GO Biological Processes -11.0190941 26 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051341 regulation of oxidoreductase activity GO Biological Processes -18.1249013 32 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051353 positive regulation of oxidoreductase activity GO Biological Processes -12.6682372 20 More
GO:0051354 negative regulation of oxidoreductase activity GO Biological Processes -6.94413823 11 More
GO:0051783 regulation of nuclear division GO Biological Processes -1.91099987 6 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0055088 lipid homeostasis GO Biological Processes -20.8046481 43 More
GO:0055089 fatty acid homeostasis GO Biological Processes -5.51502780 7 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0062012 regulation of small molecule metabolic process GO Biological Processes -26.8746473 69 More
GO:0062013 positive regulation of small molecule metabolic process GO Biological Processes -17.9792910 37 More
GO:0062014 negative regulation of small molecule metabolic process GO Biological Processes -11.3582124 24 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0070873 regulation of glycogen metabolic process GO Biological Processes -6.66615417 11 More
GO:0070875 positive regulation of glycogen metabolic process GO Biological Processes -5.72938190 7 More
GO:0071375 cellular response to peptide hormone stimulus GO Biological Processes -15.9961580 44 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0090277 positive regulation of peptide hormone secretion GO Biological Processes -6.66447400 17 More
GO:0099175 regulation of postsynapse organization GO Biological Processes -4.87425615 14 More
GO:0099177 regulation of trans-synaptic signaling GO Biological Processes -15.1793607 60 More
GO:0120035 regulation of plasma membrane bounded cell projection organization GO Biological Processes -8.54789693 60 More
GO:1900076 regulation of cellular response to insulin stimulus GO Biological Processes -8.81141992 11 More
GO:1900180 regulation of protein localization to nucleus GO Biological Processes -3.85830967 16 More
GO:1900271 regulation of long-term synaptic potentiation GO Biological Processes -4.53716649 6 More
GO:1900407 regulation of cellular response to oxidative stress GO Biological Processes -21.4526227 33 More
GO:1900542 regulation of purine nucleotide metabolic process GO Biological Processes -7.57719972 18 More
GO:1900544 positive regulation of purine nucleotide metabolic process GO Biological Processes -9.35726225 15 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1901653 cellular response to peptide GO Biological Processes -21.5212108 58 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO Biological Processes -8.56934819 8 More
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO Biological Processes -8.38095721 7 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1902882 regulation of response to oxidative stress GO Biological Processes -20.0046302 33 More
GO:1903201 regulation of oxidative stress-induced cell death GO Biological Processes -18.4601079 28 More
GO:1903202 negative regulation of oxidative stress-induced cell death GO Biological Processes -17.0330784 23 More
GO:1903426 regulation of reactive oxygen species biosynthetic process GO Biological Processes -7.23199669 13 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903531 negative regulation of secretion by cell GO Biological Processes -17.4034654 36 More
GO:1903532 positive regulation of secretion by cell GO Biological Processes -27.9542102 63 More
GO:1903578 regulation of ATP metabolic process GO Biological Processes -8.20286273 19 More
GO:1903580 positive regulation of ATP metabolic process GO Biological Processes -9.55155535 14 More
GO:1903828 negative regulation of protein localization GO Biological Processes -8.86943289 30 More
GO:1903829 positive regulation of protein localization GO Biological Processes -12.9651258 57 More
GO:1904950 negative regulation of establishment of protein localization GO Biological Processes -11.4813166 27 More
GO:1904951 positive regulation of establishment of protein localization GO Biological Processes -13.0308630 46 More
GO:1905475 regulation of protein localization to membrane GO Biological Processes -3.01117711 17 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000377 regulation of reactive oxygen species metabolic process GO Biological Processes -19.1025541 38 More
GO:2000378 negative regulation of reactive oxygen species metabolic process GO Biological Processes -8.33338139 14 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
GO:2001242 regulation of intrinsic apoptotic signaling pathway GO Biological Processes -16.0885267 23 More
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway GO Biological Processes -12.4318822 16 More
KEGG pathways: 17 records
KEGG Description Category LogP Number of genes Detail
hsa04010 MAPK signaling pathway KEGG Pathway -13.6331973 26 More
hsa04014 Ras signaling pathway KEGG Pathway -9.01898803 33 More
hsa04015 Rap1 signaling pathway KEGG Pathway -8.52596130 17 More
hsa04066 HIF-1 signaling pathway KEGG Pathway -20.6790877 23 More
hsa04068 FoxO signaling pathway KEGG Pathway -6.87449445 21 More
hsa04072 Phospholipase D signaling pathway KEGG Pathway -3.77257282 17 More
hsa04114 Oocyte meiosis KEGG Pathway -1.32019355 5 More
hsa04140 Autophagy - animal KEGG Pathway -3.52554737 16 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04810 Regulation of actin cytoskeleton KEGG Pathway -10.0068804 19 More
hsa04911 Insulin secretion KEGG Pathway -2.01839081 5 More
hsa04917 Prolactin signaling pathway KEGG Pathway -3.17844000 10 More
hsa04931 Insulin resistance KEGG Pathway -8.40376708 21 More
hsa04940 Type I diabetes mellitus KEGG Pathway -8.40921139 9 More
hsa04950 Maturity onset diabetes of the young KEGG Pathway -4.42387132 5 More
hsa05215 Prostate cancer KEGG Pathway -7.21675759 11 More
hsa05415 Diabetic cardiomyopathy KEGG Pathway -11.4800633 20 More
Drug-Gene interaction
view
Related drugs: 3 records
Drug name Interaction type Source PMID View
insulin glargine TTD view
insulin peglispro TTD view
inulin TTD view
Related studies: 9 records
Molecular factor Omics type Application Objective MI type Reference
Chr11_CpG hypermethylation epigenomics myocardial infarction[diagnosis] myocardial infarction Talens RP et al. Int J Epidemiol. 2012
Chr11_CpG hypermethylation epigenomics myocardial infarction[diagnosis] myocardial infarction Talens RP et al. Int J Epidemiol. 2012
insulin proteomics myocardial infarction[diagnosis] myocardial infarction Hughes LO et al. BMJ. 1989 Aug
insulin proteomics myocardial infarction[diagnosis] myocardial infarction Marques-Vidal P et al. J Clin Endocrinol Metab. 1995
insulin proteomics myocardial infarction[diagnosis] myocardial infarction Gruzdeva O et al. Diabetes Metab Syndr Obes. 2013
insulin proteomics type 2 diabetes mellitus[prognosis (bad)] myocardial infarction Gruzdeva O et al. Diabetes Metab Syndr Obes. 2013
insulin proteomics statin[treatment (pharmacotherapy)] acute ST elevation myocardial infarction Sposito AC et al. Sci Rep. 2019
proinsulin proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Lindahl B et al. Metabolism. 1999
proinsulin proteomics myocardial infarction[diagnosis] myocardial infarction Dunder K et al. Am Heart J. 2004
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